NEUROPROTECTIVE PROPERTIES OF PROPOFOL AND SEVOFLURAN: POSSIBILITIES OF PREVENTING THE DEVELOPMENT OF DYSFUNCTION IN COGNITIVE PROCESSES

Авторы

  • Karimova G. Kh. Автор
  • Khodjimurodova M. Yu. Автор

DOI:

https://doi.org/10.5281/zenodo.17900552

Ключевые слова:

propofol, sevoflurane, neuroprotection, cognitive dysfunction, oxidative stress, anesthesia, hypoxia

Аннотация

This article scientifically analyzes the neuroprotective properties of the anesthetics propofol and sevoflurane,
their effect on brain activity, especially cognitive processes. Cognitive dysfunction is a syndrome that occurs during
anesthesia and postoperative periods, characterized by impaired memory, attention, and cognitive function. The article
highlights the role of these two drugs in protecting neuronal metabolism, reducing oxidative stress, and controlling
inflammatory mediators. The results of the study show that propofol and sevoflurane, when used in combination or as
monotherapy, help protect brain tissue from hypoxic damage

Биографии авторов

  • Karimova G. Kh.


    EMU Medical Methodological

  • Khodjimurodova M. Yu.


    Medical Faculty Therapeutic Work

Библиографические ссылки

1. Bekmurodov A. Fundamentals of anesthesiology and clinical neurophysiology - Tashkent: Medical Publishing House,

2021. - P. 245.

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3. Zhang Y., et al. - Propofol attenuates neuronal apoptosis via antioxidant pathways - Beijing: Springer Medicine, 2022.

- p. 96-102.

4. Liu W., Chen H. - Sevoflurane-induced neuroprotection in ischemic models - Shanghai: Science Press, 2021. - p.

54-60.

5. Oripov B. - Mechanisms of oxidative stress and protection in neurochemical processes - Tashkent: Innovation, 2022.

- P. 163.

6. Smith T., Johnson P. - Anesthetic neurotoxicity and cognitive outcomes in adults - London: Oxford Medical Press,

2023. - p. 211-230.

7. Karimova N. - Physiology of the Central Nervous System - Tashkent: Medical Academy, 2020. - P. 198.

8. Huang X. - Comparative study of propofol and sevoflurane anesthesia in elderly patients - Tokyo: Academic Press,

2023. - p. 77-90.

Опубликован

2026-01-11

Как цитировать

NEUROPROTECTIVE PROPERTIES OF PROPOFOL AND SEVOFLURAN: POSSIBILITIES OF PREVENTING THE DEVELOPMENT OF DYSFUNCTION IN COGNITIVE PROCESSES. (2026). MAKTABGACHA VA MAKTAB TA’LIMI JURNALI, 3. https://doi.org/10.5281/zenodo.17900552