Chaenomeles Japonica (Thunb.) Lindl. Ex Spach mevalaridan ajratib olingan polifenol va pektin komplekslarining ichak mikrobiotasi, oksidlovchi stress va immun javobga ta’sirini molekulyar-biologik usullar asosida tadqiq etish.
DOI:
https://doi.org/10.5281/zenodo.20815022Ключевые слова:
Chaenomeles japonica, polifenollar, pektin, ichak mikrobiotasi, 16S rRNA, qPCR, oksidlovchi stress, Nrf2, NF-κB, immun javob, SCFA.Аннотация
Ushbu maqolada Chaenomeles japonica (Thunb.) Lindl. ex Spach mevalaridan ajratib olinadigan polifenol
va pektin komplekslarining ichak mikrobiotasi tarkibi, oksidlovchi stress ko‘rsatkichlari hamda immun javob markerlariga
ta’siri molekulyar-biologik yondashuvlar asosida tahlil qilindi. Tadqiqot dizaynida 16S rRNA sekvenslash, qPCR, ELISA,
HPLC-DAD/LC-MS, DPPH/ABTS, SOD–CAT–MDA biomarker tahlillari va bioinformatik-statistik baholash usullari birlashtirildi.
Adabiyotlar asosida ishlab chiqilgan eksperimental model polifenol–pektin kompleksining Bifidobacterium va
Lactobacillus kabi foydali bakteriyalar ulushini oshirishi, SCFA hosil bo‘lishini kuchaytirishi, NF-κB yo‘lini susaytirishi va
Nrf2/HO-1 antioksidant himoya tizimini faollashtirishi mumkinligini ko‘rsatadi. Maqolada namunaviy statistik jadvallar va
diagrammalar berilib, real laboratoriya natijalari kiritilganda maqola tajribaviy ish sifatida yakunlanishi mumkinligi ta’kidlanadi.
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