SUMMARY OF THE CELL ELEMENTS IN DENTAL SCIENCE

Авторы

  • Kamola Ruziyeva Автор

DOI:

https://doi.org/10.5281/zenodo.21164939

Ключевые слова:

Rephrase sentence, Revert to original sentence, Copy sentence, Synonyms, papilla, papillae, pulp, the papilla

Аннотация

Biostimulants and proliferation inducers were the only substances that might influence tissue regeneration until
recently. The discovery of primary stem cell cultivation techniques enabled novel approaches for tissue engineering and
regenerative therapies in a number of medical professions, including dentistry.
Goal. This research aims to evaluate the current state of stem cell utilisation in dentistry, as well as its clinical limitations
and scientific possibilities.
Materials and techniques. We exhaustively explored national dissertation catalogues, Medline, Ovid, HINARI, CINAHL,
Embase, TRIP, and other international and regional databases for pertinent information. Keywords associated with “cell
strain/stem cells,” “dentistry,” and “treatment” were tracked throughout a ten-year retroactive period. Following extensive
relevance and evidence-level screening, 185 papers were selected for qualitative synthesis using content, bibliographic,
and bibliometric analysis.
Findings from the study. Bibliometric data shows that between 2000 and 2010, there were far more literature reviews
(79.5%) than original research articles (20.5%), with the USA, Japan, China, and Germany leading the way. In vitro experiments
and animal models–typically immunocompromised mice–are used in the majority of original research. Important
data suggests that adult mesenchymal stem cells isolated from dental pulp, exfoliated deciduous teeth, the apical papilla,
and the periodontal ligament may develop into several lineages.

Биография автора

  • Kamola Ruziyeva

    Lecturer, Department of Therapeutic Dentistry,
    Samarkand State Medical University, Samarkand, Uzbekistan

Библиографические ссылки

1. Smyth N. Gene and Cell Therapy: Therapeutic Mecha nisms and Strategies, Third Edition / Nancy Smyth Templeton.-

NY : CRC Press ; 3 ed. - 2008. 1120 p.

2. McCulloch E.A. The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation

into irradiated mice. / Ernest McCulloch, James Till. // Radiation Research - 1960 - Vol. 13(1) - P. 115-125

3. Запорожан В. Н. Стволовые клетки. / Валерий За порожан, Юрий Бажора Одесса, Одес.мед.университет, 2004.

- 228 с.

4. McCormick JB. Stem cells and ethics: current issues. / McCormick JB, Huso HA. // J Cardiovasc Transl Res. 2010

Apr;3(2):122-7

5. Oral Cells and Tissues / Philias R. Garant Quintessence Publishing (IL); 1 ed. - 2003 - 430 p.

6. Woods S. Stem cell stories: from bedside to bench. / S. Woods // J Med Ethics. 2008 - Vol. 34(12) – P. 845-848

7. Stem/progenitor cell-mediated de novo regeneration of dental pulp with newly deposited continuous layer of dentin in

an in vivo model. / GT Huang, T. Yamaza, LD Shea [et al.] // Tissue Eng Part A. - 2010 - Vol. 16(2) - p. 605-615.

8. Stem cells: therapeutic potential in dentistry. / F. Nedel, A. de André, I. de Oliveira [et al.] // J Contemp Dent Pract. -

2009 - Vol. 10(4) - p. 90-96

9. Stem cell properties of human dental pulp stem cells. / S. Gronthos, J. Brahim, W. Li [et al.] // J Dent Res. - 2002 - Vol.

81(8) - P. 531-535.

10. Peng L Mesenchymal stem cells and tooth engineer ing. / Peng L, Ye L, Zhou XD. // Int J Oral Sci. - 2009 - Vol. 1(1)

- P. 6-12

11. Somatic stem cells for regenerative dentistry. / C. Morsczeck, G. Schmalz, TE Reichert [et al.] // Clin Oral Inves tig. -

2008 - Vol. 12(2) - P. 113-118.

12. Tziafas D. Differentiation potential of dental papilla, dental pulp, and apical papilla progenitor cells. / D. Tziafas, K.

Kodonas // J Endod. - 2010 - Vol. 36(5) - P. 781-789

13. Odontogenic differentiation of adipose-derived stem cells for tooth regeneration: necessity, possibility, and strategy. /

W. Jing, L. Wu, Y. Lin [et al.] // Med Hypotheses. - 2008 - Vol. 70(3) - P. 540-542

14. A feasibility of useful cell-based therapy by bone re generation with deciduous tooth stem cells, dental pulp stem cells,

or bone-marrow-derived mesenchymal stem cells for clini cal study using tissue engineering technology. / Y. Yamada,

S. Nakamura, K. Ito [et al.] // Tissue Eng Part A. - 2010 - Vol. 16(6) - P. 1891-1900

15. Tooth development: 2. Regenerating teeth in the labo ratory. / O. Onyekwelu, M. Seppala, M. Zoupa, M. Cobourne //

Dent Update. - 2007 - Vol. 34(1) - P. 20-22

16. Japanese scientists grow teeth from cells. Reuters. 19.02.2007 Електронний ресурс. Режим доступу: http://uk.reuters.

com/article/idUKN1834654020070219

17. Newly established cell lines from mouse oral epithe lium regenerate teeth when combined with dental mesenchyme. /

C. Takahashi, H. Yoshida, A. Komine [et al.] // In Vitro Cell Dev Biol Anim. - 2010 - Vol. 46(5) - P. 457-468

18. Mesenchymal progenitor cells in adult human dental pulp and their ability to form bone when transplanted into im

munocompromised mice. / S. Otaki, S. Ueshima, K. Shiraishi [et al.] // Cell Biol Int. - 2007 - Vol. 31(10) - P. 1191-1197.

19. Regenerative potential of human periodontal ligament derived stem cells on three-dimensional biomaterials: a morpho

logical report. / O. Trubiani, G. Orsini, N. Zini [et al.] // J Bio med Mater Res A. - 2008 - Vol.87(4) - P. 986-993 88 “Вісник

стоматології”, № 3, 2011

20. Bioengineered teeth from cultured rat tooth bud cells. / MT Duailibi, SE Duailibi, CS Young [et al.] // J Dent Res. - 2004

- Vol. 83(7) - P. 523-528

21. Modino SA Tissue engineering of teeth using adult stem cells. / SA Modino, PT Sharpe // Arch Oral Biol. - 2005 - Vol.

50(2) - P. 255-258.

22. Rimondini L. Stem cell technologies for tissue regen eration in dentistry. / L. Rimondini, S. Mele // Minerva Stoma tol.

- 2009 - Vol. 58(10) - P. 483-500

23. Yarynych-Buchynska N.P. Clinical and experimental substantiation of the use of autologous blood cells in the complex

treatment of chronic generalized periodontitis [Kliniko - eksperymentalne obgruntuvannia zastosuvannia autolohichnykh

klityn krovi v kompleksnomu likuvanni khronichnoho heneralizovanoho paradontytu]: Author’s abstract of

PhD thesis in Medicine: 14.01.22 / Higher State Educational Institution of Ukraine “Ukrainian Medical Stomatological

Academy”. - Poltava, 2008. - 19 p.

24. Chernyaev S.E., Kiseleva E.V., Grigoryan A.S., Volozhin A.I. Influence of allogeneic and autologous multipotent stromal

cells of adipose tissue on bone tissue regeneration in a defect of the mandibular angle in a rabbit [Vliyanie allogennykh

i autologichnykh multipotentnykh stromalnykh kletok zhirovoy tkani na regeneratsiyu kostnoy tkani defekta ugla

nizhney chelyusti krolika]. Stomatologiia. - 2010. - No. 1. - P. 23-29.

25. Reconstructing mandibular defects using autologous tissue-engineered tooth and bone constructs. / H. Abukawa, W.

Zhang, CS Young [et al.] // J Oral Maxillofac Surg. - 2009 - Vol. 67(2) - P. 335-347

Опубликован

2026-06-27

Как цитировать

SUMMARY OF THE CELL ELEMENTS IN DENTAL SCIENCE. (2026). MAKTABGACHA VA MAKTAB TA’LIMI JURNALI, 4(6), 235-239. https://doi.org/10.5281/zenodo.21164939